Plant Transcription Factor Database
Previous version: v3.0
Glycine soja
M-type_MADS Family
Species TF ID Description
KHM98985.1M-type_MADS family protein
KHM99309.1M-type_MADS family protein
KHN01327.1M-type_MADS family protein
KHN01468.1M-type_MADS family protein
KHN01565.1M-type_MADS family protein
KHN01566.1M-type_MADS family protein
KHN01567.1M-type_MADS family protein
KHN01568.1M-type_MADS family protein
KHN01569.1M-type_MADS family protein
KHN02784.1M-type_MADS family protein
KHN03165.1M-type_MADS family protein
KHN03468.1M-type_MADS family protein
KHN04143.1M-type_MADS family protein
KHN04240.1M-type_MADS family protein
KHN04402.1M-type_MADS family protein
KHN04459.1M-type_MADS family protein
KHN04698.1M-type_MADS family protein
KHN05212.1M-type_MADS family protein
KHN05995.1M-type_MADS family protein
KHN05996.1M-type_MADS family protein
KHN05997.1M-type_MADS family protein
KHN05998.1M-type_MADS family protein
KHN06001.1M-type_MADS family protein
KHN06442.1M-type_MADS family protein
KHN07474.1M-type_MADS family protein
KHN08794.1M-type_MADS family protein
KHN09540.1M-type_MADS family protein
KHN10636.1M-type_MADS family protein
KHN11661.1M-type_MADS family protein
KHN11873.1M-type_MADS family protein
KHN11874.1M-type_MADS family protein
KHN11875.1M-type_MADS family protein
KHN11876.1M-type_MADS family protein
KHN11882.1M-type_MADS family protein
KHN12465.1M-type_MADS family protein
KHN12467.1M-type_MADS family protein
KHN13434.1M-type_MADS family protein
KHN13937.1M-type_MADS family protein
KHN15545.1M-type_MADS family protein
KHN16637.1M-type_MADS family protein
KHN16638.1M-type_MADS family protein
KHN16640.1M-type_MADS family protein
KHN18560.1M-type_MADS family protein
KHN18666.1M-type_MADS family protein
KHN19013.1M-type_MADS family protein
KHN19014.1M-type_MADS family protein
KHN19029.1M-type_MADS family protein
KHN22365.1M-type_MADS family protein
KHN22555.1M-type_MADS family protein
KHN22598.1M-type_MADS family protein
KHN22837.1M-type_MADS family protein
KHN23183.1M-type_MADS family protein
KHN23184.1M-type_MADS family protein
KHN23185.1M-type_MADS family protein
KHN24149.1M-type_MADS family protein
KHN24197.1M-type_MADS family protein
KHN25014.1M-type_MADS family protein
KHN26066.1M-type_MADS family protein
KHN26160.1M-type_MADS family protein
KHN27245.1M-type_MADS family protein
KHN28804.1M-type_MADS family protein
KHN28973.1M-type_MADS family protein
KHN29418.1M-type_MADS family protein
KHN29766.1M-type_MADS family protein
KHN30251.1M-type_MADS family protein
KHN30252.1M-type_MADS family protein
KHN31580.1M-type_MADS family protein
KHN32593.1M-type_MADS family protein
KHN33564.1M-type_MADS family protein
KHN33576.1M-type_MADS family protein
KHN35213.1M-type_MADS family protein
KHN35923.1M-type_MADS family protein
KHN35924.1M-type_MADS family protein
KHN38970.1M-type_MADS family protein
KHN39582.1M-type_MADS family protein
KHN39969.1M-type_MADS family protein
KHN40733.1M-type_MADS family protein
KHN41666.1M-type_MADS family protein
KHN41667.1M-type_MADS family protein
KHN42718.1M-type_MADS family protein
KHN44548.1M-type_MADS family protein
KHN46003.1M-type_MADS family protein
KHN46085.1M-type_MADS family protein
KHN46233.1M-type_MADS family protein
KHN47096.1M-type_MADS family protein
KHN47673.1M-type_MADS family protein
KHN48149.1M-type_MADS family protein
KHN48409.1M-type_MADS family protein
KHN48694.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513